Suzu, a high school girl who struggles with unrequited love for her best friend Chiari, continues to work hard to become cuter. When Suzu encounters "Phantom Cosme," she changes her vibe like a different person and ends up seducing Chiari. To her surprise, the true nature of Phantom Cosme is a wicked cosmetic that grants wishes in exchange for turning the user into a puppet, stealing everyone's heart...! Suzu, who cuts through the illusion with a strong heart, creates "Twinkle Cosme," which turns her own charm into power, and transforms into "Cosmetica"! She wins back Chiari's heart. Together with Nene, the only other active Cosmetica, and Nina, the kemo-mimi (animal-eared) supporter, she begins to fight against "Phantom Labra"…!? Never give up on the heart that wants to change. Cosme Warrior, Charm On!